A Babalú-Ayé spirit amulet is associated with the Orisha Babalú-Ayé, a deity in the Yoruba religion and its derived traditions, such as Santería. Babalú-Ayé is known as the spirit of the Earth and is strongly linked with both infectious diseases and healing. His name translates to "Father, Lord of the Earth," signifying his authority over earthly matters, including the body and health.